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Chronic heart failure is closely related to impaired cardiorespiratory reflex control, including decreased ventilatory efficiency during exercise ( ˙VE/ ˙Vco2-slope) and central sleep apnea (CSA).
Classical pharmacological studies show that catecholaminergic neuron depletion in the brain stem results in decreased ventilatory response to elevated CO2 levels [ 31].
The two major contributing factors leading to exercise limitation in COPD may be the increased ventilatory requirement and the decreased ventilatory capacity [ 27].
15 In addition, concerning the association between respiration and DLB, Mizukami et al 16 reported the occurrence of decreased ventilatory responses to hypercapnia in patients with DLB.
The absence of ventilatory response to the detomidine-induced hypoxaemia may be due either to decreased ventilatory responsiveness or to decreased receptor sensitivity.
Similarly, the early administration of dexamethasone (30 min after meconium instillation) significantly reduced right-to-left pulmonary shunting, improved gas exchange and decreased ventilatory pressures in meconium-instilled rabbits compared to non-treated controls [ 50].
Similar(51)
Therefore, suitable choice or servo-control of ventilator frequency to match the spontaneous respiratory frequency is crucial for optimal ventilatory unloading, as significant phase shift in the entrained respiratory activity may decrease ventilatory efficiency and increase patient discomfort.
A good triggering performance is also mandatory while deep sedation is to be avoided to decrease ventilatory assistance duration.
The syndrome includes in variable proportion impaired diaphragmatic weakness, decreased central ventilatory drive and nearly systematically occurrence of sleep apnea.
The StO2 signal decreased during ventilatory failure until the patient was on assistance again.
Inspiratory unloading decreases ventilatory drive and work of breathing in patients undergoing mechanical ventilation.
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