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Immunohistochemistry analyses showed that T-2 toxin decreased type II collagen staining and selenium appeared to prevent the decrease in type II collagen induced by T-2 toxin in engineered cartilage.
Implantation of the scaffold in a partially nucleotomized IVD down-regulated catabolic gene expression, increased proteoglycan and type II collagen intensity and decreased type I collagen intensity in remaining NP tissue, indicating potential to retard degeneration and preserve the IVD cell phenotype.
Specifically we have demonstrated that regulating type III TGF-ß receptor expression levels is sufficient to regulate TGF-ß signaling, and that decreased type III receptor expression is a common phenomenon in human cancers, resulting in cancer progression.
In addition, we observed decreased type I collagen and fibronectin expression (Fig. S2D F), and fibroblasts accumulation (Fig. 2G I) in the skin of CD146-deficient mice.
Inhibition of IL-25 resulted in decreased type 2 T cells and macrophages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subsequent metastasis to the lung.
The majority of COL5A1 mutations introduce a premature stopcodon, resulting in nonsense-mediated mRNA decay and decreased type V (pro collagen production [5], [6].
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MSCs grown on shark ECM gels had decreased type-1 collagen mRNA as compared to all other groups.
Strictly decreasing type Lyapunov-like function, which is recently proposed by Nesic et al., is considered to obtain the tractable conditions via LMI approach.
In the epithelium, type 2 cells increased 150% during the first 3 days of repair before decreasing; type 1 cell number did not change.
Physical activity is well known to independently decrease type 2 diabetes risk.
We previously reported that PI decreases type I collagen and TIMP-1 production in human dermal fibroblasts [ 21].
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