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The decreased spleen weight was also highly significant after body weight adjustment (P = 0.004).
Since gemcitabine significantly decreased spleen size in mice infected with LP-BM5, we next examined whether the decrease in spleen size correlated with a decrease in the histopathological changes characteristic of MAIDS.
This later wave of cell death coincides with decreased spleen weight.
For example, in a commonly used mouse model, PFOA effects include decreased spleen and thymus weights, decreased thymocyte and splenocyte counts, decreased immunoglobulin response, and changes in specific populations of lymphocytes in the spleen and thymus.
When blood oxygenation returns to higher levels, [THb] decreases (spleen sequesters the RBCs).
In pinealectomized animals, thymus and spleen function were suppressed, as indicated by a decrease in the number of lymphocytes and neutrophils.
Knowledge about splenic function is important, since patients with an absent spleen or decreased splenic function are at risk of developing severe infections with a high mortality rate.
Excessive blood cell destruction caused by increased spleen function is important evidence of hypersplenism.
However, compromised spleen function has not been reported after PRRT.
Therefore, these functions are not suitable as a reliable parameter for measuring spleen function.
No screening for impaired spleen function was made at that time.
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