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The 7-valent pneumococcal conjugate vaccine (PCV7) markedly decreased resistant S. pneumoniae infections [8], [9], but recent observations suggest the emergence of non-vaccine serotypes with high levels of resistance to all approved antibiotics [10].
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Importantly, the S139A, K157A, E204A, E210A, Q242A and W244A mutants all have a significant decreased erythromycin resistant phenotype in M. smegmatis (Fig. 2D), suggesting that antibiotic resistance also depends on the ATPase activity of MABP-1.
Although classical markers of oestrogen sensitivity and proliferation were generally reduced with treatment in responsive tumours, their expression was also frequently decreased in resistant tumours [ 13, 14]; consequently they differentiated poorly between response and resistance to AIs.
Another gene, venom allergen 3, was decreased in resistant insects regardless of phosphine exposure.
Indeed, we found in the present study that the proliferative factors were decreased in resistant NSCLC.
A gene encoding a glycine-rich protein was decreased in resistant insects 15.6-fold compared to susceptible insects.
Overall, survival time was significantly decreased for resistant individuals as compared to both susceptible and unexposed groups (log-rank, p < 0.01; Table 1; Figure 1).
The number of DNA breaks produced by DX was decreased in resistant cells as compared to sensitive cells at the same cellular drug accumulation.
Moreover, protein expression of the 40-kDa soluble form of HRG was decreased in resistant cells compared with parental cell counterparts.
Survival was significantly decreased in resistant groups relative to both susceptible and unexposed groups in both replicates (p < 0.01, log-rank; Figure 2).
Consistent with the transcript levels, we found that the levels of the RelB protein were significantly decreased in resistant male CLL cells when compared with sensitive cells.
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