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Further, the intervention was effective for improving elements of QOL, such as global health status and physical functioning; it also increased emotional functioning, significantly decreased insomnia, and was similar in cost-effectiveness in comparison with usual care.
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This investigation assessed the efficacy of a technique specifically designed to change the style and content of presleep thoughts in order to reduce nighttime cognitive arousal and decrease insomnia severity.
The most common adverse events (AEs) associated with LDX included decreased appetite, insomnia, abdominal pain, and irritability [ 8].
The most frequently reported AEs were headache, decreased appetite, insomnia, and abdominal pain of mild to moderate intensity [ 31].
In addition, certain TEAEs, including decreased appetite, insomnia, decreased weight, nausea and anorexia, occurred more frequently in patients treated with lisdexamfetamine than in those who received OROS-MPH; none of these TEAEs were serious [ 13].
Adverse events with Daytrana® and Equasym XL® were mostly mild to moderate in severity and most commonly included headache, decreased appetite, insomnia and abdominal pain [ 48].
The majority of treatment-emergent AEs (> 98%) were mild to moderate in intensity, and the most commonly reported AEs included headache, decreased appetite, insomnia, and abdominal pain.
It was observed that the side effects that significantly increased in severity with MPH treatment were decreased appetite, insomnia, and headaches (in decreasing order of effect size), at p < 0.005.
The AEs reported here were similar in nature to those reported in studies of other stimulants and included decreased appetite, insomnia, headache, irritability, upper abdominal pain, and affect lability [ 10, 13, 27- 29].
However, up to 30% of children treated with stimulants either fail to show an improvement or suffer adverse side effects, including decreased appetite, insomnia and irritability and there is no evidence of long term efficacy of stimulants for ADHD.
The overall frequency of TEAEs and the frequencies of decreased appetite, insomnia, decreased weight, nausea and anorexia TEAEs were greater in patients treated with lisdexamfetamine than in those treated with OROS-MPH, whereas headache and nasopharyngitis were more frequently reported in patients receiving OROS-MPH.
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