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Age has not been a statistically significant predictor of decreased beat frequency.
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We concluded that coronary artery disease is associated with decreased beat-to-beat fluctuations in AV conduction.
The most frequently observed FHR patterns associated with CP in connection with intrapartal asphyxia are those with multiple late decelerations and decreased beat-to-beat variability.
Metoprolol significantly decreased beating irregularity and reduced arrhythmia in HCM CMs.
Inhibition of pmKATP channels with HMR-1098 prevented UA-8-mediated cellular protection against starvation-induced injury in HL-1 cells, resulting in increased lactate dehydrogenase (LDH) release, proteasome and caspase-3 activities and decreased beating rate.
Thus, the decreased ciliary beat frequency likely reflects a general impairment of epithelial function due to impaired blood supply which is underpinned by the observation of enhanced vulnerability to trauma of the epithelium in this study [15].
Mucociliary clearance therefore decreases since the thick mucous is difficult for cilia to remove; also, mucociliary transport is impaired due to a decreased cilia beat rate.
For example, at supine rest fc may be 60 beat min−1 and increase to 80 beat min−1 when standing but fc decreases 10 beat min−1 during contraction of the leg muscles in the upright position (Van Lieshout et al. 2001).
Further signs of tissue maturation include a rightward shift (to more physiological values) of the Ca2 +-response curve, increased force response to isoprenaline and decreased spontaneous beating activity.
Doxorubicin significantly decreased the beating rate of NeRCaMs in a concentration- and time-dependent manner (P<0.0005).
Since calcium and magnesium play a role in regulation of ciliary activity (controls sliding of microtubules) [ 24], decrease in transport can also be attributed to sequestering of Ca2+ and Mg2+ ions and hence decreased ciliary beating.
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