Sentence examples for decreased affinity from inspiring English sources

We observed that all tested HIF-2α mutations result in decreased affinity for PHD2 (Supplementary Figure 6a).

While the PHD1 domain preferentially interacts with unmodified H3, it also binds H3K4me3, the substrate of the catalytic domain, albeit with a decreased affinity (Table 1).

Of all the ligands investigated, only the benzoxazinone-based antagonists had decreased affinity for [A318G]OTR.

A library of single SCF mutants that span the SCF sequence was screened for decreased affinity to soluble c-Kit.

It should be noted that the ETB-Y5-mT4L construct used for the K-8794-bound K-8794-bound K-8794-bound8- and 21-fold decreastructureity for bosexhibitsd K-8794, respectively, owing to the thermostaboutzing mutation Asp1542.57Ala (Table 1).

An increase in temperature shifts the curve to the right (decreased affinity; enhanced release of oxygen); a decrease in temperature shifts the curve to the left (increased affinity).

Because of this decreased affinity, an increased partial pressure of oxygen is required to bind a given amount of oxygen to hemoglobin.

We demonstrate that the acquired resistance of chemically modified T. litoralis Sh1B DNA polymerase to DNA uracil correlates with its decreased affinity for template-strand uracil.

So 3-methyl derivative 4j showed a similar potency compared with the reference 4h while bulky lipophilic or electron withdrawing groups in the same position strongly decreased affinity.

Instead, subtle changes affected the VL/VH (variable-light domain/variable-heavy domain) interface and were likely responsible for the 5-fold decreased affinity.

Zinc II cyclen selectively stabilizes conformational state 1 of active Ras, a conformational state with drastically decreased affinity to effector proteins like Raf-kinase.