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Their in vitro ability to decrease virulence has been reported but not clinically studied.
This is not unexpected, since one strain may harbour some alleles that increase virulence, and others that decrease virulence compared with the other strain.
However, when a vaccine targets a toxin, selection can decrease virulence.
These data demonstrate that mixed clone infections can favour the evolution of social cheats, and thus decrease virulence when parasite growth is dependent on cooperative behaviours.
However, although agr dysfunction in S. aureus may potentially decrease virulence, the loss of agr function may increase the proclivity to develop vancomycin tolerance and resistance, although this has not been previously evaluated in strains of CA-MRSA.
It is plausible that when avian H5N1 and H7N9 viruses acquire stronger affinity for α2,6-SA receptors and lose affinity for α2,3-SA, this would increase their pandemic potential, but at the same time, would decrease virulence.
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On the other hand, low transmission rates in low-density host species select for less virulent disease; decreased virulence prolongs the life of the host and thus the time period for successful transmission between hosts.
Decreased motility has been shown to be connected to the decreased virulence of Campylobacter jejunum in piglets [29] and that of Db1140 S. marcescens strain in C. elegans [30].
Engineering non-virulence genes in M. tuberculosis may yield strains with decreased virulence and increased immunogenicity.
The symptoms of syphilis have become less severe over the 19th and 20th centuries, in part due to widespread availability of effective treatment and partly due to decreasing virulence of the spirochaete.
S. aureus containing the fudoh gene also had decreased exotoxin production and decreased virulence in mice.
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