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This would increase the rate of polymerisation and decrease uptake by its receptor.
Phytoplankton rapidly accumulate CH3Hg+, but rapid algal growth has been shown to dilute Hg in algal food sources and therefore decrease uptake into higher trophic levels.
Corticosteroids decrease uptake of noradrenaline at sympathetic synapses, potentiating noradrenaline's action at α1-adrenoceptors α1-adrenoceptorsonstriction and thereby decreasing fluid extravasation (Wanner et al., 2004).
Hence, down-regulation of the small GTPases might potentially be sufficient to decrease uptake of a range of agents, and restoring RhoA and related factors could possibly reverse this, even if there is no obvious impact on expression of transporters.
This includes genes that may: decrease uptake of doxorubicin (SLC22A15), enhance efflux of doxorubicin (ABCC1, ABCG2, ABCD3, ABCA1), enhance conversion of doxorubicin to doxorubicinol (AKR1B10, AKR1B1), doxorubicin deoxyaglycone or doxorubicin semiquinone (NQO1), and inhibit the ability of doxorubicin to damage tumour cells through the generation of reactive oxygen species (CAT).
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In all three, the scans showed decreased uptake of the radioactive tracer in the hippocampus, but only on that side of the brain that had previously been damaged by seizures.
Thus, deficient blood flow to a portion of the myocardium is readily detectable by decreased uptake in that area.
Renal dysfunction is reflected by decreased uptake and slope.
(d) Sagittal 18F-FDG-PET image evidenced a decreased uptake of glucose in the tumour (red arrow).
Prodrug 2 demonstrates decreased uptake in RBCs but increased uptake in HepG2 hepatocytes when compared to ribavirin.
Simultaneously during this decline, there is decreased uptake of glucose by the liver, muscle, and adipose tissue.
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CEO of Professional Science Editing for Scientists @ prosciediting.com