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Disturbance of the homeostasis of melanin synthesis by the hexameric compound of subfraction F2.4 could decrease the virulence and pathogenesis of C. neoformans.
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Impairing the secretion of EvpC will decrease the virulence of the pathogenic bacteria.
Mutations of Hcp homologs decrease the virulence of pathogenic bacteria [7], [6], [17].
Here we show that protozoan predation can decrease the virulence of opportunistic bacterial pathogen S. marcescens.
Published evidence indicates that mutations in one or more of these putative virulence genes are sufficient to decrease the virulence of S. suis.
In addition, the mutation decreased the virulence of the bacteria in macrophages in vitro and in a mice model in vivo.
Over-expression of fibronectin binding protein decreases the virulence of GAS lacking fibronectin binding protein gene resulted in reduced virulence and lack of fibronectin binding protein the surface promotes bacterial dissemination [34].
We conclude that the existing SAα2-3/6 Gal sialoglycans make the offspring of the H9N2 virus prefer entially attach to each other, which decreases the virulence.
In other bacteria, deletion of the orthologous ATPase abolishes the secretion of virulence factors thereby decreasing the virulence of the pathogen [10], [28].
By balancing the inflammatory response, hydrocortisone might also decrease the growth and virulence of bacteria [6, 7].
The deletion of the Y. pestis CO92 YscN ATPase would be expected to at least decrease the secretion of virulence factors, including Yops and LcrV, and possibly attenuate the virulence of Y. pestis CO92.
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