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Our findings support the hypothesis that the use of ketorolac in the perioperative period of cataract surgery may decrease the virulence of S. epidermidis, the most common microorganism involved in post-cataract endophthalmitis.
Mutations of Hcp homologs decrease the virulence of pathogenic bacteria [7], [6], [17].
Here we show that protozoan predation can decrease the virulence of opportunistic bacterial pathogen S. marcescens.
Impairing the secretion of EvpC will decrease the virulence of the pathogenic bacteria.
No significant difference in mortality or time to disease onset was observed in mice injected with the virulent Y. pestis KIM6+ (pCD1-kan) strain or with an isogenic hmsT y3730 (pCD1-kan) double mutant, indicating that loss of DGC activity does not decrease the virulence of Y. pestis for mice (Fig. S2).
Disturbance of the homeostasis of melanin synthesis by the hexameric compound of subfraction F2.4 could decrease the virulence and pathogenesis of C. neoformans.
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We conclude that the existing SAα2-3/6 Gal sialoglycans make the offspring of the H9N2 virus prefer entially attach to each other, which decreases the virulence.
In animal model, pretreatment of phytoestrogen-rich, Pueraria mirifica tuberous powder resulted in decreasing the virulence of rat breast tumor development induced by 7,12-dimethylbenz(a)anthracene (Cherdshewasart et al., 2007).
In other bacteria, deletion of the orthologous ATPase abolishes the secretion of virulence factors thereby decreasing the virulence of the pathogen [10], [28].
In all relevant model systems tested thus far, mutating or deleting a part of the TTSS significantly decreases the virulence of the affected pathogen.
Over-expression of fibronectin binding protein decreases the virulence of GAS lacking fibronectin binding protein gene resulted in reduced virulence and lack of fibronectin binding protein the surface promotes bacterial dissemination [34].
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