As shown above, the accumulation of NADH facilitated reaction NADH16 and restrained reaction NADTRHD, thus decreasing the turnover of NADH and NADPH gradually (Table 2).
IL-3 disproportionately decreased the turnover of transcripts annotated to the GO categories cell cycle (p<2×10−10), RNA processing (10−6), and other related categories.
(B ) miR-92 overexpression decreases the turnover of c-Myc protein.
The decreased mobility of vinculin also decreased the turnover rate of talin (Cohen et al., 2006) and integrins in FA (Humphries et al., 2007).
However, Tet increased the level of sequestosome 1 and decreased the turnover of LC3, indicating the blockade of autophagic flux in the degradation stage.
A predominant decrease in ECM activity might mean that FS decreased the turnover and/or generation of ECM in the lung through its anti-inflammatory and anti-apoptotic activity.
To gain insight into the non-genomic mechanism by which Nur77 increased the protein levels of β-catenin, the protein synthesis inhibitor cycloheximide (CHX) was used to determine whether Nur77 decreased the turnover of β-catenin.
It has been proposed that Cif mediated cell cycle arrest provides enteric pathogens, such as EPEC and Y. pseudotuberculosis, with a stable platform by decreasing the turnover rate of intestinal epithelial cells (Samba-Louaka et al., 2009).
This might be achieved in several ways, by increasing the growth rate (which decreases the turnover time of the stable regulators) or tagging proteins for active degradation, which would tend to make four lifetimes more similar on the scale of mRNA turnover time.
As previously reported [ 16], we found that cycloheximide treatment alone reduced Mcl-1 protein levels and we observed that addition of adiponectin to cycloheximide-treated cells resulted in an increase in Mcl-1 levels, confirming that adiponectin decreased the turnover of Mcl-1 (Fig. 2c).
