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If the iteration point ( x_{k + 1} ) does not satisfy the filter rule, the backtracking line-search procedure will be used to decrease the trial step sizes unless the iteration point ( x_{k + 1} ) does not meet the filter rule.
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Including all cases reduces the false-positive rate below 5% but also decreases the trial power, and leads to underestimates of vaccine efficacy (figure 3C).
Indeed, an attempt by European observers to discourage the death penalty would decrease the legitimacy of the trial for the Iraqi people.
A large difference in the intervention effect at the level of school nurses and/or schools is expected to decrease the precision of the trial comparison.
As the Jacobs et al. study [ 43] looked at patients who were deteriorating on oral therapy, we assumed that patients' 6MWD would decrease during the trial if they were not given any new treatments.
If this is true, then decreasing the outcome of a reward trial (from 4 to 2 food pellets) while maintaining the level of temptation (6 pellets), should maintain the levels of alternation between T and S trials, while decrease the levels of mutual cooperation (R trials).
Obviously, abandoning trials will decrease the power of a meta-analysis since trials that are eligible for analysis cannot be taken into account.
Finally, smaller phase 2 trials decrease the precision of estimating the probability of phase 3 success and the clinical benefit effect size.
If the membrane fluctuation decreased the energy, the trial fluctuation is accepted and the procedure is reiterated starting from the new membrane configuration.
Additionally, we decreased the inter-trial interval in the present experiment, now ranging from ∼1200 to ∼1500 ms instead of ranging from 2050 to 2350 ms (and we did not include a neutral condition).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com