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Although (A_{1}) does not affect the number of (R_{0}), reducing (A_{1}) can decrease the infection level of (I_{2}) (see Figure 4).
In order to decrease the infection and especially reinfection rate several methods have been developed, at which rising occurrences of antibiotic resistances among bacteria make antibiotic-based strategies more and more questionable (Jamsen et al. 2010; Schmidmaier et al. 2006; Hetrick and Schoenfisch 2006; Poelstra et al. 2000).
It requires stringent adherence to all precautions to decrease the infection rate.
According to this meta-analysis, initial moderate nutrient intake (33.3% to 66.6% of goal energy) as compared to HE may reduce mortality, and a higher protein intake combined with HE (≥0.85 g/kg per day) may decrease the infection rates.
Initial moderate nutrient intake (33.3 to 66.6% of goal energy), compared to high energy, may reduce mortality, and a higher protein intake combined with high energy (≥0.85 g/kg per day) may decrease the infection rate.
Antibiotic-loaded bone cement works as a local antibiotic-carrier with the function of a drug-delivery-system to achieve high antibiotic levels locally [ 12- 14] and to decrease the infection rate [ 12].
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High-energy intake combined with high-protein intake reduced the infections (RR, 1.25; 95% CI, 1.04 to 1.52; P = 0.02); however, when the daily protein intake was similar in both groups, a high-energy intake did not decrease the infections.
Injection of PRS1 dsRNA before infecting mosquitoes by P.berghei significantly decreases the infection intensity (p = 0.004) but the effect on prevalence was not significant (p = 0.18) (Fig. 2B, C).
Preoperative oral arginine and n-fatty acids improves the immunometabolic response and decreases the infection rate.
These strategies were compared with constant treatment strategies and were shown to be more beneficial in silico, i.e., they either decreased the infection establishment probability or the dosage of the drugs.
A possible reason for this may be because raloxifene therapy decreases the frequency of subsequent fractures, thereby improving mobility and decreasing the infection rate.
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