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Firstly, chronic hypoperfusion, which has been demonstrated in TgPAC-Notch3R169C mice [ 17], may decrease the functioning of ion pumps involved in ionic homeostasis, leading to intramyelinic oedema.
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Her research shows that women taking hormone replacement therapy have an increased risk of dry eye, perhaps because estrogen may decrease the function of the meibomian glands.
However, antibiotics used during therapy decrease the functions of the immune system.
Acetylation can either increase or decrease the function or stability of the proteins or protein protein interaction (Glozak et al. 2005).
MSCs decrease the function of DC to secrete IL-12, which is important to promote an effective cellular immunity by activating and differentiating T cells[ 45].
However, when electrophysiological experiments were performed at 35 °C in HEK 293 cells, PMA decreased the function of these receptors.
The hinge enhanced the functions of CARs against certain antigens while decreasing the functions of other CARs.
DOI: http://dx.doi.org/10.7554/eLife.03502.007 10.7554/eLiFigure02.008 Figure 3 figure supplement 1. Decreasing the function of the core components of the SET1/MLL complex leads to a reduction in type II neuroblasts.
Furthermore, inhibition of AKT decreased the function of NF- κB, which is capable of transcriptional regulation of the BCL-2 gene [ 25].
Typical for MPS contractures of fingers (so-called claw hands) were also observed decreasing the function, efficiency, and skills of the hands.
Furthermore, to decrease the pathological functions of DKK1 in peptides, the osteoclast-forming assay was performed.
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