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We hypothesized that the combination of clemizole with other anti-HCV agents can increase the antiviral effect over that achieved with each drug alone and could also decrease the emergence of viral resistance.Luciferase reporter-linked HCV replication assays were used to study the antiviral effects of drug combinations that included clemizole.
The combination therapy beta-lactam and amikacin failed to decrease the emergence of resistance unlike in an in vitro study [20].
More importantly, this strategy can decrease the emergence of drug-resistant cells.
Double drug therapy has been used to increase spectrum, for possible synergy, and to decrease the emergence of resistance.
Theoretically, primary systemic therapy could inhibit the rapid growth of metastases after surgery and may decrease the emergence of chemoresistant clones of cells.
SDD may decrease the emergence of antibiotic resistance [ 36], but an increase in pathological bacteria (enterococci and coagulase-negative staphylococci) is of concern [ 37].
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Simultaneous use of both inhibitors considerably decreased the emergence of resistant clones in a dose-dependent manner.
The once-daily single-tablet regimen significantly improves the adherence and decreases the emergence of resistant viral populations.
BubR1 knockdown significantly decreased the emergence of polyploid cells under OS in p53-depleted cells (Fig. 3B and C-d).
Suppression of SOX2 sensitizes cells to erlotinib-mediated apoptosis, ultimately decreasing the emergence of acquired resistance, whereas its ectopic expression reduces drug-induced cell death.
When they are used in combination with antimicrobial agents, inhibitors of these pumps should reverse resistance, enhancing the potency and expanding the spectrum of activity of antimicrobial agents while decreasing the emergence of new resistance [ 50].
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