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However, localized delivery system with high regional drug level may greatly decrease the dose of drug, leading to higher safety and lower cost.
The study was, therefore, amended to decrease the dose of gemcitabine to 800 mgivengiven on days 1 and 8 in a 21-day cycle.
To date, despite the ready availability of rhBMPs for clinical use, the dilemma facing clinicians and the biotechnology industry is how to find delivery systems that can further decrease the dose of BMPs and produce a more sustained release pattern as well as serve as a more effective scaffold for osteoconduction.
A few (4.0%) decided to decrease the dose of the salmeterol/fluticasone combination.
GPs are also free to decrease the dose of either drug if appropriate.
It may also be beneficial to decrease the dose of steroids in order to minimize fluid retention.
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Agents that block NO synthesis during septic shock increase arterial pressure and decrease the doses of vasoconstrictor catecholamines needed to maintain arterial pressure [ 27].
Proton therapy would decrease the dose to other parts of the body, including the heart, liver and intestines and trachea by up to 80%, the PTC said.
Initially, lesions stabilised but when we decreased the dose of corticosteroids to 10 mg (in the third week of treatment), new lesions started to appear (Fig. 2).
Nanomedicine-based combination anticancer therapy can synergistically improve antitumor outcomes through multiple-target therapy, decreasing the dose of each therapeutic agent and reducing side effects.
The rest of the side effects reverted by decreasing the dose of D-PCA.
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