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It tends to decrease the bounds of variation of model parameters and therefore is effective in resolving sharp boundary to some extent (Zhdanov 2002).
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It does not decrease the upper bounds in the case of a general HMM but leads to a significant improvement of the software for Markov models.
From (3.18), it is obvious that we can increase a (i.e., p1 or τ) to decrease the upper bound of PEP, which in turn reduces the symbol/bit detection error.
TSC1-TSC2 can decrease the GDP-bound form of RHEB (Ras homolog enriched in brain) and increase its GDPase activity.
Then, we will decrease the upper bound ρ to as small a value as possible to approach its lower bound for the noise-filtering ability ρ0, i.e., to get ρ0 by minimizing ρ (or ρ0 = min ρ) indirectly.
First, let the upper bound g of (5) (Basar and Olsder, 1999; Chen et al., 2002) be (6) We will first solve the sub-minimax problem in (6) and then decrease the upper bound g as much as possible to approach its minimax solution.
A smaller number of items turns the matrix denser, decreasing the efficiency bounds of BicPAM.
Similarly to the one-population models, we decreased the lower bounds on some parameters (e.g., T and m) in an effort to speed convergence for the IM and ISO model fits in datasets with larger sample sizes.
Such an approach may decrease the dependency of mineral-bound nutrient sources, which would benefit long-term sustainability in food production.
This led them to postulate that a HIF-1-dependent increase in CSB level would decrease the level of p53-bound p300 and consequently increase the level of p300 available for HIF-1.
Given its opposing role in promoting the ATPase activity of BiP, we tested whether loss of DNAJC3 function, which would be predicted to decrease the production of ATP-bound BiP, might restore ER balance and ameliorate neurodegeneration in Sil1−/− Purkinje cells.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com