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The PMRP biospecimens are overwhelmingly Caucasian therefore this is appropriate for our application, however this emphasis may decrease the applicability of this assay to other populations.
Using clinical guidelines to define usual care can be helpful in standardizing comparator treatments; however, this may decrease the applicability of the results to real-life settings.
Numerous limitations that may decrease the applicability of PPV and/or SVV in daily clinical practice have been described in critically ill patients.
If such low tidal volumes (6 to 8 ml/kg) were to be adopted widely to ventilate patients in operating theatres, this would significantly decrease the applicability of dynamic parameters for GDFT.
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However, because Eqs. 7 and 8 assume infinitely long tubes, for cristae with L/a∼1 the exponent α in Eq. 9 differs from 1 decreasing the applicability of Eq. 8 (the deviation is in the range of several percent).
The inclusion of a relatively small number of studies in different regions (China, Japan and Germany) might have decreased the applicability of our results across different ethnicities.
The major limitation of our analysis involves the inclusion of a relatively small number of studies on Asians, which might have decreased the applicability of our results across different ethnicities.
Older patients and those with a comorbidity are generally excluded from randomized clinical trials used to generate the evidence for clinical guidelines, decreasing the applicability of trial results to real-world populations (23).
Among the innovative technologies developed in order to decrease the costs and broaden the applicability of photovoltaics, the dye sensitized solar cells have gained a flourishing interest for their potential as an economically and environmentally viable alternative to traditional devices.
The results strongly suggest that it would be hazardous to decrease the cutoffs of LSM applicability for the diagnosis of advanced fibrosis as suggested by others [15].
The paper also addresses a conceptual design of a protective structure able to decrease the containment vulnerability and provide a preliminary assessment of the applicability of such concept.
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