Abnormally long pauses and slow polymerization were generally correlated with increased termination and decreased pause times, whereas fast elongation was associated with decreased termination.
Thus, mutations of -12C or -16C residues will decrease the stability of the hair-pin structure resulting in decreased termination of transcripts and consequently, increased expression of embA and embB encoded gene products.
Indeed, heat shock has recently been shown both optically and biochemically to increase the escape of paused Pol II into the gene body at the Drosophila Hsp70 locus without decreasing termination of paused Pol II, arguing against a role for termination in the regulation of the accumulation and escape of paused Pol II.
Thirdly, a mixed model can be envisioned where a decrease in termination and acceleration go hand in hand as Pol II progresses in the gene body.
In comparison with baseline values, circulating sCD74 levels decreased significantly upon myocardial reperfusion (p=0.013), followed by an intermittent increase 15 min after weaning from CPB and another long-lasting decrease after termination of surgery (p=0.001).
The fraction of men those benefits have been terminated increases from about 1percentto3percentcent between the 1990 and 2004 panel, which is consistent with a decrease of terminations due to death and retirement, and an increase of terminations due to medical disqualifications since the late 1980s (Autor & Duggan, 2006).
We find that gene expression correlation between promoter-proximal and promoter-distal genes at the protein level decreases as termination increases.
To determine whether a brief self-administered cognitive coping and relaxation intervention (CCRI) would lead to decreased treatment termination in in vitro fertilization (IVF) patients compared with routine care (RC).
From the 2nd week of exposure, SGR of TE-1-exposed fish increased to further decrease toward the termination of the test.
The average methylation density over all 24 samples showed a decline in DNA methylation near transcription start sites (TSS), followed by a sharp rise and steadily increasing methylation in the gene body region which ended in a sharp decrease at transcription termination sites (TTS) to a lower plateau (Additional file 1: Figure S1a).
