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In addition, cell-autonomous mechanisms may decrease susceptibility of cancer to immune effector mechanisms.
We also demonstrate that expression of Arabidopsis genes encoding AOS, AOC, and JAR1, which are involved in the synthesis and modification of JA, only modestly decrease susceptibility of soybean roots to SCN.
We show that specific Arabidopsis genes, namely A tNPR1, AtTGA2, AtICS1, and AtPR5 which encode components of SA regulation, biosynthesis, and downstream effectors, can decrease susceptibility of soybean to SCN when expressed in transgenic soybean roots.
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For both pests, results of laboratory diet bioassays reveal significantly decreased susceptibility of field populations to Cry1Ac, yet field control failures of Bt cotton have not been reported.
It has been observed that there is naturally occurring decreased susceptibility of HIV-1G to protease inhibitors [53].
The decreased susceptibility of HMDMs to YopJ/YopP (Fig. 1 and Fig. 2) is in agreement with previous Y.
Interestingly, overexpression of miR-155 resulted in a strongly decreased susceptibility of the CD4+ Th cells to nTreg cell-mediated suppression (Fig. 4B).
The complex mutational patterns are however difficult to interpret, due to the many different drug resistance mutations [6] and the varying levels of decreased susceptibility of these mutations to different drugs.
For instance, SV40 miR-s1 targets viral early transcript T antigen with perfect matches, which results in decreased susceptibility of SV40-infected cells to cytotoxic T lymphocyte killing [30].
On the other hand, the S18Y polymorphism may be associated with decreased susceptibility of sporadic PD in a dose-dependent manner, although the evidence for this may be weak [15] or moderate at most [16].
Unfortunately, the trend of decreased susceptibility of S.aureus to vancomycin is not uncommon.
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