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In the bat fly – bat system, numerous properties interrupt the linkage of parasite to host and should decrease specificity.
In the limit of an infinite training pool, maximizing Youden's index will place the classification threshold at a point where any shift to the left will increase sensitivity less than it will decrease specificity.
Although K8.1 EIA would have further increased sensitivity, it could also decrease specificity [33].
Adding MUAC just seemed to decrease specificity.
We would expect CAD to increase sensitivity but decrease specificity.
In general, lowering the cutoff value will increase sensitivity, but consequently decrease specificity and vice versa.
Similar(49)
Of course, this comes at the cost of a decreased specificity and has to be decided application specific.
Double reading generally increased sensitivity at the cost of decreased specificity.
Given the danger of misidentifying a cancer patient (which could lead to death), tests are generally designed to ensure a high sensitivity by decreasing specificity (i.e. increasing false positives to ensure that as many positives are identified).
By applying MTV-corrected cutoff values of T/N ratio (1.23), diagnostic performance could be maintained without decreasing specificity in small-sized lesions (Table 2).
Finally, MTV-corrected cutoff values of the T/N ratio can improve diagnostic performance of 11C-MET PET/CT without decreasing specificity especially in small lesions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com