Exercise is effective to decrease sleep complains and treat chronic insomnia, it demonstrates comparable effectiveness on sleep problems when compared with hypnotics.
Commonly used GABA agonists such as propofol and benzodiazepines (Table 1) increase total sleep time and decrease sleep latency; however, these decrease N3 and REM sleep stages [53,54].
In a study of intern work hours, the traditional intern work schedule involving work shifts longer than 24 hours and a mean of 77 to 81 work hours per week was compared to a schedule designed to decrease sleep deprivation (15-hour shifts at the most, with 60-63 work hours per week) [61].
Yet entering the bedroom at night with a clear mind has been suggested to decrease sleep issues and increase the quality of an insomniac's sleep.
First, we overexpressed Hcrt using a heat-shock inducible promoter, which was previously shown to decrease sleep in zebrafish larvae (Prober et al., 2006).
Commonly used GABA agonists such as propofol and benzodiazepines (Table 1) increase total sleep time and decrease sleep latency; however, these decrease N3 and REM sleep stages [ 53, 54].
