Exact(1)
The fact that under basal conditions heat-evoked foot withdrawal latency is fairly stable (grey traces Fig. 1) suggests that activation of AMPA receptors alone is not enough to drive sensitization and indeed in rat dorsal horn neurons, inhibiting AMPA receptors with NBQX has also been observed to only decrease sensitization at high doses under non-inflammatory conditions [28].
Similar(59)
Either baclofen (2.5 and 5 mg/kg) or SKF 97541 (0.1 mg/kg) decreased sensitization to cocaine.
Also, TRPC3 inhibition would alter this behavior through decreased sensitization, resulting in reduced nocifensive action.
Of note, universal leukoreduction has not decreased sensitization in patients to any significant degree [ 78].
This theoretical mechanism of action of ketamine has shown to decrease central sensitization and allodynia in pain conditions, which has motived clinicians to use it as treatment for migraine.
There was no decrease in sensitization with fractionation, even using fractions as small as 5 Gy.
Importantly, DA signaling is critical for the actions of ethanol and cocaine in flies: disruption of DA signaling blunts the locomotor activating effects of ethanol, alters cocaine sensitivity, and decreases cocaine sensitization [16] [18].
An emerging role for CGRP and neurogenic vasodilatation in chronic migraine is suggested by findings obtained by the injection of botulinum neurotoxin type A (BoNTA) into the rat craniofacial muscles, a procedure that decreased mechanical sensitization mediated by glutamate and CGRP-induced neurogenic vasodilatation [64].
Our management protocol aimed at decreasing the sensitization, increasing range of motion and functional restoration.
This suggests a decreased Ca2+ sensitization of the smooth muscle cell contractile apparatus.
A change in neck pain could result in beneficial changes in overall pain perception and a decreased pain sensitization.
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