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Moreover, elevated corticosterone concentrations have been shown to decrease prolactin levels and parental care [ 31].
Bromocriptine, a dopamine agonist has been investigated in several studies for its potential to decrease prolactin levels.
We have also found that aripiprazole added to dopamine raising antipsychotics can decrease prolactin levels and lead to women regaining their menstrual periods.
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It became soon clear that decreased prolactin levels under treatment with the dopamine receptor agonist bromocriptine ameliorated the severity of premenstrual mastodynia, an effect not seen in the placebo treated patients [3, 10].
This strategy is highly effective at decreasing prolactin levels and improving related side effects.
Coincident with the induction of the above mentioned genes associated with angiogenesis, analysis of plasma at this time revealed decreased prolactin levels.
A double-blind, placebo-controlled study of low-dose bromocriptine therapy (2.5 mg/day) showed a significant decrease in prolactin levels associated with a significant decrease in disease activity [ 25].
Conveniently, Masoud and Fakharian [44] found a significant decrease in prolactin levels during the headache attack in migraineurs.
It was hypothesized that the increased dopaminergic activity is responsible from prodromal, clinical and postdromal symptoms [19, 43] and, therefore, a decrease in prolactin levels should be expected during migraine attacks.
ER knockout mice develop a hypoplastic mammary gland phenotype as a consequence of a pituitary gland dysfunction associated with a decrease in prolactin levels [ 40].
Some studies reported few adverse events related with hiperprolactinemia [ 50], this is probably due to the decrease of prolactin levels with the long term treatment [ 51].
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