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The linear fit in Fig. 3 indicates a diminishing trend of the foci-to-dose ratio versus age; however, regression analysis showed that the decrease of the foci-to-dose ratio versus age was not statistically significant (p = 0.204).
Smaller chambers will have lower costs and will allow the final-focus magnets to be closer to the target with decreased size of the focus spot and of the driver, as well as drastically reduced costs of IFE electricity.
Almost all DNA damage in all the tissues analyzed was effectively repaired 24 hours after exposure, evident by the decrease of the γ-H2AX foci to near control levels (Fig. 1).
It has been shown that the decrease of γH2AX foci number per cell after IR correlates with the rejoining of DSBs measured by pulse field gel electrophoresis (PFGE) (Löbrich et al. 2010).
The only noticeable difference was a twofold decrease of RNaseY foci located at the septal region (Table 2).
Here, the increase of the gap width of the beam-defining slit by a factor of 2 could be shown to result in a decrease in size of the focus approximately by a factor of 2. The result is in agreement with Fourier optics where the focus size decreases linearly with an increase of the numerical aperture indicating full or a high degree of spatial coherence of the beam.
We also found that 53BP1 foci were induced in a LET -and fluence-dependent manner and fewer foci were induced in G0 cells than G1 cells, however, the decrease of foci in 24 h after irradiation was highly relevant to the type of particles.
In addition, the efficacy of chemotherapy and the decrease of pathologic lesion foci were not significantly related with total dose or single dose of cisplatin or the interval between chemotherapy and surgery (Table 5).
This resulted in a dramatic decrease of BRCA1/BARD1/RAD51 foci, but not of γH2AX foci (Fig. 9A, top and bottom panels).
We did not observe a general decrease of Rad52 foci in nmt41-xlf1.AA.
Knockdown of SPOP also resulted in a decrease of RAD51 foci, suggesting a selective loss of function of SPOP-F133V in HDR.
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