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There is also a decrease of specificity, and this relates to the important theme of folktaxonomy.
The ROC curve shows the extent to which the method is able to obtain as many positive results (increase of sensitivity) as possible at the expense of increasing false positive predictions (decrease of specificity).
19 Knottnerus 20 explained the increase of sensitivity and decrease of specificity by referral processes in a methodological framework.
The association of these three markers increased sensitivity with a slight decrease of specificity [ 4- 6, 18].
For the examination at rest, a lower cutoff value would have led to an increase of sensitivity but a crucial decrease of specificity.
This result is consistent with the decrease of specificity for single nucleotide mismatch with increasing probe length, as shown in Figures 3 and 7.
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It should be observed that when the number of clusters is decreased, the rates of specificity and precision decrease.
In general, paired screening trial bias tends to strongly increase the sensitivity, while slightly decreasing the estimate of specificity.
Importantly, miR-22 upregulation decreased the expression of specificity protein 1 (SP1) and estrogen receptor 1 (ESR1) and vice versa, suggesting that they are targets of miR-22 [ 78].
The availability of mutants that decrease substrate specificity of T7 RNAP further broadens the range of chemically modified NTPs used as substrates for RNA synthesis.
The inhibition of cholinesterases by alkyl isocyanates shows a pattern of decreased specificity with decreased alkyl chain length.
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