Exact(4)
Western blot analysis and immunofluorescence showed a marked decrease of key gap and adherens junction proteins (connexin43 and N-cadherin, respectively) in mice subjected to severe septic injury.
In summary, our results overall confirm the previously reported atrophogenic effect of glucocorticoids via decrease of key ECM components in the skin.
It is possible that cancer cells show more generally a stronger decrease of key kinases than that observed in Hs68 cells after treatment.
As HDACi induced a strong decrease of key proteins involved in cell cycle control and mitosis, we verified whether these effects were extensive to primary GBM cultures.
Similar(56)
Concomitant decreases of key enzymes of Krebs cycle and major complexes of oxidative phosphorylation provided evidences for alteration of mitochondrial metabolism in the old skeletal muscle.
Glycerol alleviated the activity decrease of the key enzymes in the mixture.
Despite the marked decrease of the key enzymes involved in oxidative phosphorylation, the ATP level in the Al-stressed cells did not undergo a corresponding reduction.
In contrast, the age-dependent decrease of both key mitochondrial proteins and bioenergetic competence is considerably attenuated in daf-2 e1370) daf-2 e1370ls.
SE depression temporally coincides with upregulation of inflammatory cytokines and decreases expression of key mitochondrial ROS scavengers.
Our findings suggest that the reduced insulin secretion observed in the GK rat may be partly due to upregulated miRNA expression leading to decreased production of key proteins of the insulin exocytotic machinery.
Additionally, transcript levels were reduced in skin of SKO mice for genes involved in fatty acid synthesis, elongation and desaturation, which may be attributed to decreased abundance of key transcription factors including SREBP1c, ChREBP and LXRα.
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