Sentence examples for decrease of function from inspiring English sources

The G118A substitution led to a drastic decrease of function, as shown by a complementation test in the Zn-hypersensitive mutant zrc1Δ.

This can be described in text as an inactive enzyme instead of a decrease of function relative to wildtype as in the below example sentences: "Replacement of Trp-125 or Trp-175 with arginine leads to a nonactive enzyme".

For example, [T]hey said I had kind of an ADD process where, you know, when I'm concentrating, especially on, you know, something that's relatively mundane, there's a decrease of function in the front part of my brain, so that it lends itself to having more difficulty with staying on task with boring things (C014).

Among patients who consented, DNA was extracted and 6 loss of function (LOF) or decrease of function (DOF) SNPs, in CYP2A6 (rs28399433 [risk allele C]), CYP2B6 (rs28399499 [G], rs35303484 [G], rs35979566 [A], rs3745274 [A]), and CYP3A4 (rs4646437 [A]) were assessed using the Illumina VeraCode™ Genotyping Assay.

Patients with loss or decrease of function single nucleotide polymorphisms (SNPs) in the above genes were assigned a risk score based upon the number of SNPs present weighted relative to whether CYP2B6 (main metabolism pathway) and/or CYP2A6 and CYP3A4 (accessory pathways) were involved.

Single nucleotide polymorphisms (SNPs) in CYP2B6, CYP2A6 and CYP3A4 exist that result in loss of function (LOF) or decrease of function (DOF), which associate with slower EFV metabolism and consequently increased drug levels (di Iulio et al., 2009, Arab-Alameddine et al., 2009).

Hence, both decrease-of-function of lamin A/C and gain-of-function of aberrant lamin A protein induced laminopathies that are associated with mesenchymal cell lineages during zebrafish early development.

As for the LMNA function in our zebrafish progeria model, it should be noted that the decrease-of-function of LMNA showed specific developmental defects without any significant induction of SA-β-gal i.e. embryonic senescence.

Hence, it is not entirely surprising that the decrease-of-function of lamin A/C by MO1 and the gain-of-function of zlamin A-Δ8 by MO2 could have such distinct effects on cell cycle, apoptosis and senescence in zebrafish embryos.

The condition in Eq. (27) ensures the sufficient decrease of the function value per iteration.

Because of a further decrease of kidney function requiring haemodialysis treatment, plasmapheresis was performed.