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A change of policy was shown, mainly due to the decrease of false negative results.
In 3 TUs, the number of correctly forecasted landslides diminishes, but this drawback is partially balanced by a decrease of false alarms.
The first mechanism is analogous to the mechanism driving the decrease of false positives in SIM-1.
Obviously, the benefit of genomic-wide integration is the substantial improvement in coverage of true positives and the decrease of false positives.
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Reclassification analysis showed that the main improvement was the decrease of false-positive results and that non-metastatic patients were reclassified into lower BSI groups.
Newer generation kits decrease rates of false positive testing[ 21].
We tried to use postprocessing procedure to improve prediction quality and decrease numbers of "false positive" and "false negative" results.
This drawback is not compensated by the slight decrease of the false positive rate.
Firstly, removing a large number of unknown features will allow for more complete annotation of the metabolome, and decreased reporting of false positives.
True positives increase over time while false positives stay constant, leading to a decreasing fraction of false among the positive findings (26% for SIM-R vs. 19% for pooled data from EXP-1S, EXP-1G and EXP-1S*; p = 9e-5).
This leads to the testing of hypotheses with increasing prior probabilities, which in turn leads to a decreasing fraction of false positives among the positive findings in the literature.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com