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The first whooping cough vaccines consisting of whole inactivated B. pertussis were licensed in the mid-1940s and led to a dramatic decrease of disease incidence [1], [2].
The baseline-to-treatment study design used here may be subject to certain probabilistic phenomena such as regression to the mean, i.e. an expected decrease of disease activity in a given patient population with high disease activity at study onset.
Recently, TG101348 treatment resulted in a significant decrease of disease burden in a phase III trial for patients with myelofibrosis.
MC patients showed a decrease of disease activity as well as an improvement in quality of life after acupuncture treatment in this study.
A further decrease of disease activity after the second course has been previously suggested [ 10], but limited data are available on the effect of retreatment before flare.
Further decrease of disease activity was observed at the end of year 1 and year 2 with mean DAS28-ESR of 4.0 and 3.7 at these respective time points.
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However, the increase was not steady, with a peak of 1.94/100,000 in 2001 followed by a decrease, indicating a true decrease of disease-specific deaths.
Specific antigen vaccination by administration of the target antigen in aqueous solution has resulted in significant decreases of disease severity in animal models of experimental allergic encephalomyelitis, type I diabetes, and several forms of antigen-induced arthritis, even if administered after the initiation of symptoms.
We assumed that rotavirus detection rates decreased with decreasing severity of disease by approximately 25% for each severity decrease, as previously described [ 7].
Pulmonary instillation of SAgAs decreased disease score, improved weight gain, and decreased incidence of disease in EAE mice compared to pulmonary delivery of hyaluronic acid polymer, LABL, or PLP.
Sufficient fruit and vegetable intake may be the most important public health message for the decrease of chronic disease [ 55].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com