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The decrease of the transcription of Neurod1 is consistent with the enrichment of NSCs and an overall decrease of differentiation level in the HMF-exposed cells.
Concomitant with the decrease of differentiation genes, numerous genes, which are typical for neuronal tissues or the neural crest, were induced.
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Well differentiated malignant tumours did, however, tend to stain more strongly than did poorly differentiated neoplasms, thus suggesting that the number of binding sites per cell tends to decrease with decreasing degrees of differentiation.
We demonstrate that a low level of RAS activation increases SOD3 mRNA synthesis that then gradually decreases with increasing levels of RAS activation and the decreasing degree of differentiation of the cancer cells.
To investigate whether IL-2 recovers from the decrease of Treg differentiation caused by 1,25(OH)2D3, we added recombinant IL-2 (rIL-2) on the culture medium of CD4+ T cells in the presence of TGF-β and 1,25(OH)2D3.
It is well established that the decrease of osteoblast differentiation is associated with increase adipocyte formation.
The results showed that the ablation of RHAU in germ cells caused the increase of G4 structures and thus resulted in the decrease of spermatogonial differentiation.
There were 8% of IL-17A+ cells in PI3KγKD/KD Th17 cultures compared to 22% in WT cultures, demonstrating a 64% decrease of Th17 differentiation from PI3KγKD/KD T cells.
In addition, our findings suggest that ERK inhibition can counteract the decrease of myogenic differentiation markers, as has been shown by Penna et al. [ 52].
The only pathway with decreased degree of differentiation among populations was the "antigen processing and presentation" pathway.
Therefore, these results suggest that abnormal Fhit expression is associated with decreasing degrees of differentiation in CRCs.
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