Interestingly, giving a single injection of old blood to young mice resulted in decreased physical performance, decreased brain cell development, and decreased liver function.
The clinical course was characterized by increasing jaundice and decreasing liver function parameters, particularly clotting factors.
Inclusion criteria for patients with chronic liver disease, recruited by hepatologists, were decreased liver function and elevated serum ferritin levels.
Tyrosine and phenylalanine are mainly metabolized in the liver, suggesting that decreased liver function might result in increased plasma levels.
Therefore, we suggest other mechanisms, rather than inflammation of the liver or an overall decreased liver function, may be responsible for the noted abnormalities.
Based on the analysis of cumulative mortality we conducted separate analyses for patients with a GEC <1.75 mmol/min (decreased liver function) or ≥1.75 mmol/min.
Lower baseline platelet counts, which reportedly correlate with decreased liver function and lower TPO level [ 17], account for lower on-treatment platelet counts.
With an increasing Child-Pugh score and decreasing liver function, total doses were reduced to 35 Gy in Child B patients [ 12].
Importantly, however, significantly higher levels of total CK-18, indicative of necrosis, were observed in the non-surviving group with decreased liver function.
