Exact(7)
While these disruptions of the imported alleles were observed only in ∼10% of clones, ISR are likely to have an impact on allelic diversity, because they have the potential to significantly decrease linkage between individual polymorphic sites.
If there was any effect at all, it appeared to decrease linkage quality.
An alternative way to decrease linkage disequilibrium is to intersperse extra generations of neutral mixing between rounds of selection.
Advanced Intercross Lines AILL) are produced by repeated intercrossing of F2 animals and successive generations, which decrease linkage disequilibrium in a controlled manner.
In particular, the use of a larger number of inbred founder lines may decrease linkage disequilibrium in the initial experimental populations, leading to higher power and better resolution without adding additional rounds of recombination.
While in practice it is not feasible to experimentally increase the recombination rate of individuals, the experiment can be designed to increase the opportunity for individual chromosomes to recombine and thus decrease linkage between QTL and neighboring neutral variants.
Similar(53)
Furthermore, wild populations of D. melanogaster show a cline in the frequency of the most common mth haplotype along the latitudinal gradient of the U.S. east coast [24], a pattern that decays with decreasing linkage disequilibrium both 5' and 3' of the mth locus [25].
The performance of haplotyping methods can deteriorate on databases with decreasing linkage disequilibrium (LD) rates.
Data cleaning techniques were further investigated to determine their individual effect in improving or decreasing linkage quality.
Recombination not only reduces interference between QTL, but also decreases linkage disequilibrium between QTL and neighboring neutral loci.
This step is critical as non-pre-processed linkage variables result in a decreased linkage proportion because true matches are more frequently missed [ 22].
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