Sentence examples for decrease life span from inspiring English sources

Conversely, obesity has been shown to decrease life span in humans [35] as well as C. elegans [25], while in both species serotonin signalling has been implicated in body fat accumulation [36].

Rahman et al. find that OGA inactivating mutants increase life span, while OGT inactivating mutants decrease life span.

However, higher levels decrease life span and can induce cellular toxicity, manifested by increased expression of the JNK-signaling molecule Puc phosphatase and induction of dnaJ-H.

However, several studies have shown that many conditions that increase ROS do not decrease life span, in worms and in mice [ 42, 43, 48].

Because the expression of the testis-specific forms is virtually nonexistent in other tissues, we postulate that even their ectopic expression might decrease life span.

Strikingly, these effects of dominant mutations on life span were highly dependent upon environment, since in the W cohort the dominant mutations tended to decrease life span in both males and females (Supplementary Figure 3; Supplementary Table 7).

Under these circumstances, a decreased life span would not be surprising.

Furthermore, there is the cost of spending five hours in dialysis three times a week, the cost of a decreased life span with kidney failure, the cost of increased health risks with a lifetime of a suppressed immune system.

The phenotype is associated with the decreased life span we detected in mutant worms.

Ontology analysis revealed that strains with significantly decreased life span were enriched for genes in several biological processes, including vacuolar function, protein catabolism, and pH homeostasis.

Reduced levels and/or activity of a protein named Klotho is associated with decreased life span, premature aging and occurrence of age-related diseases.