As for (i), in the neighborhood of baseline conditions, diffusion and clearance appear to play a comparable role, because comparable variations in the scleral diffusion (increase) or scleral clearance (decrease) are required to increase drug peak concentration (notice the slope of the curves in Figure 6).
Thus a model order reduction is required to decrease the dimensionality and to enable an efficient numerical simulation.
A compensatory decrease in incidence is required, if the incidence increase in the screened group is due only to advancement of the time of diagnosis (lead-time) [ 11].
Unless an assumption is made that the other taxa in the Rhodymeniophycidae lineage have experienced nuclear genome size decrease, an explanation is required to account for the larger genome sizes in the Ceramiales.
Notice that a decreasing autocorrelation function is required, as it is the case in fading channels.
Therefore, nowadays relaxants are only administered in the ICU for specific indications, such as when decreased muscle tone is required, for treating patients who fight the ventilator and in order to allow permissive hypercapnia.
Both processes are controllable, the control system showing robustness when increase or decrease in production capacity is required, or operating conditions change.
In early stages of chondrocyte differentiation, an increase in p38 and decrease in ERK1/2 activity is required for the progression to cartilage nodule formation in chick limb buds [ 17].
Thus, monosaccharide formation decreases and less insulin is required for further metabolisation, leading to a reduction of food-induced postprandial increases in blood glucose and insulin.
When durations or temperatures increase, product quality decreases and more effort is required to deliver products in time and with the right quality.
