Different formulations aid in decreasing irritation, which is the main side-effect that hinders continued use of this class of drugs.
We evaluated the efficacy of a novel catheter with a trefoil profile to decrease urothelial irritation and delay catheter associated urinary tract infections by comparing it with a conventional catheter in the rabbit model.
Indomethacin (IMC) has been shown to reduce post-operative inflammation and to decrease intraocular irritation after cataract extraction and in cystoid macular edema; however, the clinical use of its most commonly used eye drops is limited due to topical side-effects that include burning sensation, irritation and epithelial keratitis.
56, 57 This reduction increases treatment tolerance and decreases local irritation, although local irritation has been described as well tolerated since the first cases 50, 51 and there are cases of good results with application to the eyelid and penis.
In patients, the presence of therapy dogs decreased pain, irritation, and stress and other depressive symptoms.
Sustained-release technology is one of the efficient methods for decreasing stomach irritation by drugs.
Drug companies are looking for ways to improve compliance by decreasing the irritation factor of topical retinoids.
It is unclear whether this advantage is due to increased efficacy or increased compliance due to decreased localized irritation from a lower concentration of BP.
Orthodontic bonding to enamel surfaces resulted in significant improvements in treatment such as greater patient comfort, elimination of the need for pre-treatment tooth separation, decreased gingival irritation, improved oral hygiene and aesthetics, and reduced chair time (Reynolds and von Fraunhofer, 1976; Rajagapol et al., 2004).
The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids.
