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Macrophage numbers continued to decrease after the peak at day 3 in the ischemic hind limb thereby explaining the decrease in uptake of 99mTc-PyP.
In terms of potential differences in uptake due to addition of food, Skjolding et al. [72] found that feeding resulted in a net decrease in uptake of AuNP but also gave rise to a higher deviation in uptake which could imply sorption of AuNP onto algae.
The tm3004 mutant shows a decrease in uptake of fatty acid specifically into triglyceride, while the uptake into other phospholipids was not affected.
This decrease in plaque area observed in ApoE−/− Nrf2−/− mice was associated with a significant decrease in uptake of modified low density lipoproteins (AcLDL) by isolated macrophages from ApoE−/− Nrf2−/− mice.
While we found the anticipated decrease in uptake of particles in carrier cells [15], we noted largely unchanged rates of 2° transfer, in turn resulting in up to a 20-fold proportional increase in the efficiency of 2° transfer to 293T cells (Fig. 3A).
4T1 breast cancer cells also showed a 3.6-fold decrease in uptake of spherical capsules as compared to the spherical cores.
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Interestingly, in the presence of serum, no decreases in uptake of PNA5-Fl or PNA6-Fl, and only minor decreases in uptake of PNA3-Fl and PNA4-Fl were detectable.
Studies by Ott et al.[ 7 ] in assessing early response to therapy (within 14 days of commencement of chemo-radiotherapy) found a decrease in uptake (SUV) of greater than 35% indicated a major pathological response with a 3-year survival of 70%, compared to a 3-year survival of only 35% in the non responders.
According to the slopes of the regressions, a 10% decrease in IPF from the mean observed during saline infusion resulted in 3.8, 7.3, and 10.4% decreases in uptakes of acetate, glucose, and triacylglycerol, respectively.
In the latter, especially the cerebellum and the temporal lobes as regions that are located right between the earcups experienced a rather uniform decrease in uptake values of approximately 10%%, while more remote regions were less affected.
Following treatment with wild-type PCSK9 at a concentration of 1 μg/ml, there was a moderate decrease in LDL uptake of 28%, whereas a concentration of 20 μg/ml was required to get a near-maximal decrease in LDL uptake of 69%.
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