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If the rebound response was directly driven by excitatory synaptic input, a hyperpolarized membrane potential would be expected to result in a decrease in the spike response after the IO stimulation.
In these conditions, we showed a decrease in the rheobase current, a decrease in the latency to the first spike, a leftward shift of the current – firing frequency plot, a decrease in the spike threshold and an increase in the slope of the ramp potential evoked by a subthreshold depolarizing current pulse.
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(3) Past learning inhibits future learning, presumably by causing a learned decrease in the simple-spike responses of Purkinje cells (Medina and Lisberger, 2008) that could reduce the probability of the CS responses that would instruct learning.
During the presentation of visual stimuli (vertical black bar on left) the main changes induced by rTMS are associated with a decrease in the number of spikes separated from 1 to 3 ms. Elsewhere in the intervalogram there are more subtle changes generally related to a decrease of interspike intervals.
Peri-stimulus time histograms (PSTH) of the GoCs (n = 16, 100-ms bin) shows a decrease in the number of spikes after train pulse stimulation.
This indicates that the decrease in the number of spikes is not due to a reduction in Rin as an increase in this measure would predict more excitability, not less.
Representatives of the ACLU and the city's police union said they did not think there was a direct connection between the decrease in stops and the spike in violence.
What factors control the decrease in spike output with decreasing stimulus intensity?
When the conductance density of the KCNQ2/3 model was reduced by 25%, more action potentials were generated for the same current injection (Fig. 7F) but the decrease in spike frequency adaptation was not as substantial as in the model of KCNQ2+syntaxin 1A (Fig. 7C).
Neurons with a low percentage of bursts, i.e. the proportion of spikes in bursts was below 40 50% (n = 18), showed a significant increase in the percentage of spikes in bursts when rTMS@1Hz was applied, as it is shown in Figure 3A (21.1±2.2% to 24.0±2.2%, P<0.05, paired t-test) and therefore a decrease in the percentage of tonic spikes (78.9±2.2% to 76.0±2.2%, P<0.05, paired t-test, Figure 3B).
If the postsynaptic spike appears before the presynaptic spike, a decrease in the weight occurs assuming that inverse dependency exists between pre- and postsynaptic spikes.
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