Sentence examples for decrease in the potency from inspiring English sources

The logistic function provides a good fit to the log b1 concentration-B*max curve, with R2 = 0.997 A decrease in the affinity of b1 for B, ΔKD (reducing from a high value of 100 to 10) produces a corresponding decrease in the potency of b1, such that both the maximum achievable output of the system, and ratio producing half maximal output, are significantly reduced.

Mutation Q134A3.32 caused a moderate decrease in the potency of OxA (22.3-fold) without affecting its efficacy.

Mutation of the conserved R10 to alanine resulted in a decrease in the potency of OxB with respect to both OX1 and OX2 receptors.

Mutation of the nonconserved S18 to alanine resulted in a decrease in the potency to OX2 but had no effect on OX1.

Mutation of this residue to alanine resulted in a severe decrease in the potency of OxA (see Table 1) and in 64.5 and 63.0% decreases in its Emax values for OX1 and OX2, respectively.

This chemical competition may possibly reduce the apparent sensitivity of the applied antagonist and account for the decrease in the potency of α2-adrenoceptor antagonists with age (Pottorf et al., 2000b).

This is consistent with the cytotoxicity assays where a decrease in the potencies of all of the drugs tested was observed in the TSQ relative to the TSP (Table 1).

The Y311A6.48 mutation results in a large decrease in both the potency and the efficacy of OxA and correlates with the same effect of the L31A mutation.

The Y311A6.48 mutation resulted in a large decrease in both the potency and the efficacy of OxB and correlates with the same effect of the L26A mutation, which results in the abolishment of both the potency and the efficacy of OxB.

Mutations of Val-349 to Ala or Leu alter the size of the pocket and lead to an increase or decrease, respectively, in the potency of indomethacin.

Although these data show a slight decrease in the inhibitory potency of PEG-KR21 relative to that of KR21 for gp120 sCD4 interaction, overall the inhibitory potencies of both peptides for the interaction of gp120 with sCD4 and 17b are fairly similar.