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The luxS isogenic mutant of A. hydrophila, which we prepared by marker exchange mutagenesis, showed an alteration in the dynamics and architecture of the biofilm formation, a decrease in the motility of the bacterium, and an enhanced virulence in the septicemic mouse model.
Caveolae disruption caused approximately 2-fold and 10-fold decrease in the motility of SNU-449 and SNU-475, respectively.
Depletion of IMP3 led to a significant decrease in the motility of Hs766T, a PDAC cell line derived from a lymphatic metastasis.
We believe that this reflects a general decrease in the motility of the cells, such that they cannot move apart following HGF stimulation although other aspects of the program may remain intact.
The only other published study, which to our knowledge examined the effect of S100A6 on motility, showed a decrease in the motility of one of three osteosarcoma cell lines after adenoviral-mediated overexpression of S100A6 (Luu et al, 2005).
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Our results showed that the treatment of bovine sperms with kallikrein led to a decrease in the progressive motility when compared with the caffeine and pentoxifylline treatment and control groups.
We observed that transfection of Panc-1 cells with an annexin 2-targeting siRNA was accompanied by a 50% decrease in the cell motility index compared with control siRNA#1 as assessed by modified Boyden chamber assay.
Up and downregulation of cofilin correlate with increases and decreases, respectively, in the motility of tumor cells [ 32].
Concomitant decrease in the fish spermatozoa motility and velocity was also shown at the same concentrations, and a dramatic increase in DNA fragmentation was recorded by Comet assay (Hulak et al. 2013).
YK-4-279 treatment of LNCaP cells resulted in a significant decrease in cell motility in the scratch assay, while no effects were observed on the motility of the negative control cell-line, PC-3 (Fig. 4b).
38 The decrease in motility of the esophagus and lower esophageal sphincter pressure both contribute to GERD, a common disease in octogenarians that may lead to aspiration.
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