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We did not observe any significant decrease in the lifespan of ndg-4 mutants following RNAi against lipl-4 (Fig. 3B; Table S2).
However, more recent studies found a ∼30% decrease in the lifespan of the sod1 /– mice but not in that of the sod1+/– mice.
Previous studies have suggested multiple causes including iatrogenic blood loss, depression of serum iron levels and erythropoietin production, and a decrease in the lifespan of erythrocytes [ 3- 9].
First, oxidative stress has been associated with increased aging at the molecular level as shown by the deletion of the superoxide dismutase 1 (Sod1) gene producing a decrease in the lifespan of mice [ 27].
We observed a decrease in the lifespan of ref(2 P od2 and ref(2 P od3 mutants maintained on normal food as well as in food containing rotenone, a mitochondrial complex I inhibitor or paraquat, a pesticide linked to PD by epidemiological studies.
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We scored the two cohorts of zprogerin transgenic fish (no genders identified; Cohort 1, n = 102; Cohort 2, n = 54) in comparison with their wild-type siblings (no genders identified; Cohort 1, n = 22 and Cohort 2, n = 46), and found significant decreases in the lifespan of the zprogerin transgenic animals (Cohort 1, P<0.0005; Cohort 2, P<0.0001, log rank test) (Fig. 8).
Deletion of CTA1 was shown to cause a decrease in the chronological lifespan (CLS) [ 22].
Methionine restriction also causes a slight decrease in the average lifespan but does not affect reproductive fitness in Drosophila (Zajitschek et al., 2013).
The inverse death rate of infected cells is reflective of our growth potential since a decrease in the cell's lifespan (a decrease in the inverse death rate) leads to a decrease in the total number of progeny.
14 Positive effects of estrogen in bone include a decrease in the production and lifespan of osteoclasts (the bone resorbing cells), stimulation of osteoblast (the bone forming cells) activity and additional effects on calcium homeostasis.
One by one nutrient replenishment to otherwise severely calorie-restricted fruit fly demonstrates that only amino acids addition is effective in decreasing the lifespan and increasing fecundity, indicating that the amount of calories per se does not affect the lifespan [ 47].
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decrease in the market
decrease in the production
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decrease in the cultivation
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decrease in the frequency
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