Sentence examples for decrease in the internalization from inspiring English sources
A decrease in the internalization of FAM-Aβ42 was observed in GT1-7 cells with decreased LRP1 levels, and in MEF2 cells compared to MEF1.
In our studies we have used three concentrations (10, 50 and 100 µM) of EIPA and found no decrease in the internalization of mitochondria into cardiomyocytes suggesting that in cardiomyocytes, macro-pinocytosis does not play a role in mitochondrial internalization.
The elevated TGFA level may simply reflect inhibition of TGFA binding to EGFR by cetuximab and subsequent decrease in the TGFA/EGFR internalization.
There was a pronounced decrease in the maximal levels of internalization in the presence of PTx (30 ± 6% reduction vs. 10 μM NECA internalization, n = 5) but no significant change in the potency of the agonist (pEC50 = 6.55 ± 0.21, n = 5).
Regarding clathrin and CAV1 inhibition through the use of MCD and CPMZ, we observed that the disruption of caveolae and the inhibiton of clathrin-heavy-chain conformations led to a decrease in IGF1R internalization (figure 3B).
Decreasing NRP internalization leads to a decrease in the rate at which VEGF is internalized due to being bound to NRP1 or NRP2.
Although we did not measure extracellular levels of IGF-II, our results show that ribozyme-mediated down-regulation of M6P/IGF2R leads to a decrease in IGF-II internalization, supporting the above possibility.
Further collapse of the contact would further decrease the internalization and bring the receptor density above critical, triggering contact expansion.
The α isoform of GRK4 phosphorylates receptors in the absence of agonist activation, resulting in an increase in the level of receptor internalization, and a decrease in the total number of receptors.
The decrease in the ApoE level is explained by an accelerated internalization and degradation of ApoE when LRP is overexpressed.
Thus, the downregulation of NG2 proteoglycan may result in the internalization or disruption of AMPA receptors,which may lead to the decrease of neuron-NG2 cell synapses.
