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In fact, current theories trying to explain other impulse controls disorders such as compulsive drug taking postulate that in the transition from recreational drug use to addiction a decrease in the functionality of reward systems occurs prior to the instatement of compulsive drug-seeking behavior [9] [11].
In addition, a decrease in the functionality of both the whole muscle [ 110, 111] and single fibres [ 112] also takes place.
We assume that an increase or a decrease in the activity of a biochemical pathway is accompanied by a respective trend for increase or decrease in the functionality of most of the genes forming the pathway, whose fluctuations in expression affect the given pathways' state.
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The specific binding of the PH domain to PIP2 should, in principle, decrease the functionality of the accessible PIP2 at the plasma membrane.
During repetitive episodes of hypoxemia and hypercapnia, the optic nerve may have a progressive decrease in functionality of the ganglion cells and successively of the retinal nerve fiber layer [ 16, 17].
Introduction: Inhibition of mitochondrial Complex I is described in human and animal sepsis.1,2 This may be responsible, at least in part, for the decrease in mitochondrial functionality seen in sepsis.
Data suggest that functional memantine concentration in the human brain is relatively small; together with the intrinsic pharmacology as a weak and uncompetitive inhibitor at the NMDA receptor [ 76], suggesting a small decrease in NMDA functionality. Figure 9A shows the effect of a decrease of 0.5% in the excitatory NMDA receptor and 1% in the inhibitory NMDA receptor on the network performance.
Note that you may notice a decrease in functionality on the site.
This is due to a decrease in the content of surface functionalities and the formation of well-ordered carbon sheets.
The age-dependent increase in VGF-expression could serve as mechanism that counterregulates the decrease in functionality of T lymphocytes.
We speculate that the age-dependent increase in VGF-expression could serve as a mechanism that counterregulates the decrease in functionality of T cells during senescence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com