Meanwhile for the SMS, when this surfactant is increased, the pH decreases in the formulation.
Disintegration time, T50 and T90 were decreased in the formulations containing mannitol and Kollidon® CL-SF, but increased with galenIQ™-721 and sodium starch glycolate, respectively.
The drug loaded nanoparticles depicted no distinctive peak of the felodipine in the DSC profiles owing to the decreased crystallinity in the formulations and/or drug solvation in the amorphous carrier as well as solid state interaction induced by heating.
Intensity of pure lipid peaks was also decreased in the SLN formulation.
Plume angles determined by mass showed a significant decrease in size as ethanol increases which correlates to the decrease on vapor pressure in the formulation.
Both melting point and CI of GTCC in the formulation decreased with decreasing concentration of GTCC.
Both melting point and CI of CoQ10 in the formulation decreased with decreasing ratio CoQ10/GTCC from 100%CoQ10to25%CoQ10oQ10; conversely, the peaks broadened.
The most evident difference is the drastic decrease of FWI in the formulations including the organic solvent, in strict agreement with results reported in the literature [14, 18, 19, 25].
The 3D views of the response surface are shown in Figs. 6, 7. From this study, it is observed that the lowest adhesion value corresponds to Formulation G which contains pure surfactant; thus, increasing the mass fraction of surfactant in the formulation decreases the adhesion.
The wetting time of tablets compressed from mixtures prepared by simple blending increased as the amount of Neusilin US2 in the formulation decreased.
