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The advantages of combination therapy include coverage of a broad spectrum of pathogens and, theoretically, synergistic activity with a decrease in the emergence of resistant strains.
Notably, this result, together with the decrease in the emergence of mucoid variants in MPA-T1 (Figure 2A and 2B), suggest that after the elimination of G5-SSR426, mutagenesis of mucA was no longer the major pathway of mucoid conversion.
This in turn may lead to a decrease in the emergence of organisms with antimicrobial resistance.
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This intervention may result in healthy animals, decrease the emergence of antibiotic-resistance in foodborne pathogens, decrease the supply of antibiotics to animals, and reduce the rates of transmission of infectious diseases from animal farms to humans.
This could be interpreted as suggesting that the periods without treatment gave a competitive advantage to drug-sensitive cells, which in fine decreased the emergence of fully resistant tumours.
The combination therapy beta-lactam and amikacin failed to decrease the emergence of resistance unlike in an in vitro study [20].
As no single-spore isolation was carried out, the observed decrease in the production of perithecia reflected the emergence and the invasion of female-sterile mutants.
Redox probe studies now show that during Caenorhabditis elegans development, a temporal wave of H2O2 production occurs in the larval stage, followed by a decrease in H2O2 upon emergence of the adult (Fig. 4A) (58).
Recent experiments report a decrease in ESBLEs emergence following decrease in cephalosporins use [10].
SDD may decrease the emergence of antibiotic resistance [ 36], but an increase in pathological bacteria (enterococci and coagulase-negative staphylococci) is of concern [ 37].
More importantly, this strategy can decrease the emergence of drug-resistant cells.
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