When up to 25% of the edges were removed randomly from the network, there was no decrease in the precisions of the centrality metrics for the top 20 genes.
The decrease in degree centrality is independent of the network size, and is a consequence of the smaller network connectedness.
ECB recovery: While in the crisis and the post-crisis periods "LTRO" is the highest ranked G concept, during the recovery period, it suffers a drastic decrease in betweenness centrality ranking, appearing now as a marginal concept (M).
Minor comments: The example of calculating stress in the network of oncogenes in the manuscript should comply with experimental functional relevance, e.g. a decrease in bridging centrality is observed for key intermodular nodes upon heat shock response or oxidative stress, partially disintegrating overlapping modules into local communities which alters the centrality statistics of the nodes,.
The example of calculating stress in the network of oncogenes in the manuscript should comply with experimental functional relevance, e.g. a decrease in bridging centrality is observed for key intermodular nodes upon heat shock response or oxidative stress, partially disintegrating overlapping modules into local communities which alters the centrality statistics of the nodes,.
While "LTRO" suffers a drastic decrease in betweenness centrality (becoming an M concept), "MRO" and "refinancing" become G concepts.
A decrease in closeness centrality of components has been observed as a consequence of increased distance between pathways throughout evolution [ 80].
This is not true for the MRSA positives, whose units decrease in centrality with time.
As the networks become increasingly scale-free (i.e., the variation in node degree in the network increases), the trend we could deduce is a decrease in the correlation coefficient values between BWC and each of the four centrality metrics (especially in the case of Eigenvector centrality under all the three correlation measures).
Network centralization [ 47] reflects how much variation is there in the centrality scores (in our case, betweenness centrality) among the nodes.
