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The primary end point was time required to achieve a 50% decrease in symptom score.
Response to treatment is defined as a decrease in symptom score to one equal to or below the score that has been identified in healthy individuals[ 21].
Ecallantide-treated subjects reported a mean decrease in symptom score at 4 h of 0.81 compared with a decrease of 0.37 in placebo-treated subjects (P = 0.01).
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In the ADHD literature, a 30% decrease in symptom scores is accepted as a good indicator of a clinically significant symptom reduction [ 44].
We defined LRs/HRs from the decrease in symptom scores when treated for two weeks in the pollen season, using previously described methods [ 23].
The large pragmatic STAR*D study conducted in the USA showed that even with protocol driven treatment, first line therapy with a selective serotonin reuptake inhibitor (SSRI: citalopram) in over 2500 patients was associated with remission in only 28%, and response (defined as a 50% decrease in symptom scores) in less than 50% of patients [ 6].
This may be due to the change in weighting reflected by a smaller increase in function scores (+11.31) relative to a greater decrease in symptom scores (-14.85), as shown in column 6, and/or because of other changes and additions to the questions in the FIQR.
We define decreases in symptom scores at least one year from baseline as symptom improvements and increases in scores at least one year from baseline as symptom worsening.
IT was associated with improvement in symptom scores, decrease in rescue medication use, and decreased nasal eosinophilia.
For CAARS change scores, therapeutic change is indicated by negative numbers, i.e., a decrease in the symptom score; 3).
Good response was defined as a 50% decrease in the symptom score on either the Hamilton Depression Rating Scale (HDRS) or 8-item scale of atypical symptoms.
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