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Thus, there was indeed a decrease in stimulus specificity.
In WKY/NHsd, exposure to 1 mg/kg was associated with a short-term decrease in stimulus control that was more pronounced in males than in females.
In control animals, a more than 20-fold decrease in stimulus intensity (from 1.30 to 0.14°) led to ∽85% reduction in the size of the responsive ensemble.
In contrast, the same decrease in stimulus intensity after SWE led to only a 50% reduction in the size of the response ensemble.
The advantage of kinetics was that, independently of an absolute value, decreasing values were related to survival; this outcome is suggestive of a decrease in stimulus to inflammation and a decrease in exposure to bacterial toxins.
Possibly, most relevant to the present results due to similarities in experimental procedure are the studies by Holene et al. which observed a long-lasting decrease in stimulus control and an increase in activity and responses with short IRTs in male, but not female, offspring of DA/OLA/HSD females mated with Lewis rats and gavage-fed 5 mg/kg PCB 153 every second day from PND 3 to 13 [ 73, 74].
Similar(53)
A similar decrease in stimulus-evoked release of dopamine was observed in SHR nucleus accumbens shell in vivo [ 54].
Decreases in stimulus efficacy using ChR2R were likely due to network adaptation, rather than changes in ChR2R-mediated photocurrents (Mattis et al., 2011).
For example, increases in the energy of a somatosensory stimulus increase N2 amplitude, whereas decreases in stimulus energy and small displacements have little effect (Torta et al. 2012; Ronga et al. 2013).
Individual OSNs of C. elegans and cockroaches function as bipolar detectors that selectively respond to either increases or decreases in stimulus intensity (Tichy et al., 2005; Chalasani et al., 2007).
This likely resulted from alleviation of the insulin resistance and a decrease in the stimulus to insulin secretion by glucagon.
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