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coInsm1 mutant islets and immature islets also displayed a similar decrease in sensitivity to tolbutamide, a blocker of ATP-sensitive potassium channels (Fig 4E and F).
This effect was not due to an overall decrease in sensitivity to looming since running was intact (Fig. 5d and Supplementary Fig. 5a and b).
There also may be present the phenomenon of masking; this is a decrease in sensitivity to one odour after exposure to another (for example, a strong-smelling disinfectant).
Untreated controls at the 2 intervals showed a mean decrease in sensitivity to cold of 3.6°C and 4.1°C.
Human TAS2R16 alone has at least 17 polymorphisms, including an allelic variant at amino acid 172 that is associated with a 2-fold decrease in sensitivity to β-glucosides and is linked to alcohol dependence10, 14, 15.
However, stainless steel exhibited a dramatic decrease in sensitivity to blue dot because of the intrinsic instability and high acidity of this solution.
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Study 3a showed that participants' anxious attachment predicted larger decreases in sensitivity to reward after a sad mood induction.
Both alleles might combine synergistically to cause profound decreases in sensitivity to analgesics.
However, the site of action of 5-HT in these studies is unclear, although human functional imaging studies have implicated the dorsomedial prefrontal cortex (PFC) as a site for the proposed involvement of 5-HT in increases or decreases in sensitivity to negative feedback (Evers et al. 2005; Macoveanu et al. 2013).
This modification resulted in a significant decrease in Erk1/2 sensitivity to Ins stimulation and a better fit to the experimental data.
We believe that we were unable to detect significant association of σ with the fourth DST, ybjX, due to the substantial decrease in sensitivity relative to the standard ChIP method.
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